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Clinical response and total and unbound plasma concentrations after lidocaine overdose
D K Armstrong1, D L Bremseth, J J Lima
1Laboratory of Applied Pharmacokinetics, University of Southern California School of Medicine, Los Angeles.
Therapeutic Drug Monitoring
|January 1, 1988
Abstract:
Plasma and unbound concentrations and hemodynamic and CNS effects were monitored in a patient after overdose of 2 g of lidocaine HCl infused during 1 h. Hypotension, decreased heart rate, tremors, and nonresponsiveness to stimuli were observed at plasma and unbound concentrations of 17.7 and 12.0 micrograms/ml. The half-lives of decline of plasma and unbound concentrations were 3.8 and 2.7 h; the difference in half-lives was due to nonlinear plasma protein binding.