Related Experiment Video
Updated: Dec 29, 2025
06:06
Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
2.9K
Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study
Raluca Cosgarea1,2, Robert Pollmann3, Jusra Sharif4
1Department of Periodontology, Philipps-University Marburg, Marburg, Germany. ralucacosgarea@gmail.com.
Scientific Reports
|February 5, 2020
Summary
Photodynamic therapy (PDT) offers a safe, non-invasive treatment for oral lichen planus (OLP), significantly reducing lesions and improving quality of life by decreasing inflammatory T cells and CXCL10 levels.
Area of Science:
- Immunology
- Dermatology
- Photomedicine
Background:
- Oral lichen planus (OLP) is a chronic inflammatory condition causing significant discomfort.
- Current OLP treatments have potential side effects.
- There is a need for safe, non-invasive OLP therapies.
Purpose of the Study:
- To evaluate the clinical and immunological efficacy of photodynamic therapy (PDT) for OLP.
- To assess PDT as a safe and non-invasive alternative treatment for OLP.
Main Methods:
- A prospective pilot study involving 20 OLP patients.
- PDT administered in 4 sessions over 14 days.
- Analysis of peripheral blood and lesional T cells before and after PDT.
Main Results:
- Significant reduction in OLP lesion size and clinical scores (ABSIS, Thongprasom-score).
- Marked improvement in quality of life (QOL) for patients.
- Decreased CD4+ and CD8+ T cells in lesions, reduced CXCL10 plasma levels, and diminished activated T cells and IL-17-secreting T cells.
Conclusions:
- PDT effectively reduces OLP lesions and improves patient quality of life.
- PDT demonstrates local and systemic anti-inflammatory effects in OLP.
- PDT is a promising novel therapeutic option for OLP.
