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Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Appendicitis-I: Introduction01:22

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
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Gastritis III: Clinical Manifestations and Management01:23

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Related Experiment Video

Updated: Dec 29, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

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Eosinophilic gastroenteritis with persistent abdominal pain: a case report.

Yoshiaki Sasaki1, Hiroki Kajino1

  • 1Department of Pediatrics, Abashiri-Kosei General Hospital, Japan.

Journal of Rural Medicine : JRM
|February 5, 2020
PubMed
Summary

Eosinophilic gastroenteritis (EGE) diagnosis requires gastrointestinal mucosal biopsies showing at least 20 eosinophils/HPF. This finding is crucial for diagnosing EGE, even with only persistent abdominal pain.

Keywords:
abdominal painchildrenendoscopyeosinophilic gastroenteritis

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Area of Science:

  • Gastroenterology
  • Allergy and Immunology
  • Pediatric Medicine

Background:

  • Eosinophilic gastroenteritis (EGE) is a rare gastrointestinal disorder characterized by eosinophilic infiltration of the gut.
  • Diagnosis can be challenging due to nonspecific symptoms and normal endoscopic appearance of the mucosa.
  • Eosinophil counts in peripheral blood and tissue are key diagnostic markers.

Purpose of the Study:

  • To highlight the diagnostic criteria for eosinophilic gastroenteritis in a pediatric case.
  • To emphasize the importance of mucosal biopsy in confirming EGE.
  • To discuss the role of eosinophil counts in diagnosis.

Main Methods:

  • Case presentation of a 9-year-old boy with intermittent abdominal pain.
  • Analysis of peripheral blood eosinophil count.
  • Endoscopic examination of the upper and lower gastrointestinal tract.
  • Histopathological examination of mucosal biopsies from multiple gastrointestinal segments.

Main Results:

  • Peripheral blood eosinophil count was marginally elevated (660 cells/µL).
  • Endoscopic evaluation revealed normal-appearing mucosa throughout the gastrointestinal tract.
  • Mucosal biopsies demonstrated significant eosinophilic infiltration (≥20 eosinophils/HPF) in the terminal ileum, colon, esophagus, and duodenum.

Conclusions:

  • Definitive diagnosis of EGE requires evidence of eosinophilic infiltration in gastrointestinal mucosal biopsies.
  • A threshold of ≥20 eosinophils/HPF in relevant tissues is critical for diagnosis.
  • EGE diagnosis should be considered in children with persistent abdominal pain, supported by biopsy findings, allergy history, and eosinophil counts.