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S-100-Negative malignant pulmonary granular cell tumor: A case report
Bo-Guen Kim1, Ju Yeun Song1, Sungmin Zo1
1Division of Pulmonary and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Respiratory Medicine Case Reports
|February 5, 2020
Summary
Malignant pulmonary granular cell tumors (GCTs) are rare and challenging to diagnose. This case highlights an S-100 negative, non-neural type malignant GCT, emphasizing diagnostic difficulties.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Malignant pulmonary granular cell tumors (GCTs) are exceptionally rare.
- Distinguishing malignant from benign GCTs, and neural from non-neural types, presents diagnostic challenges.
- Most GCTs are neural-type and S-100 positive, but a subset lacks S-100 expression.
Observation:
- A 77-year-old woman presented with dyspnea and chest discomfort due to a right main bronchus obstruction.
- Bronchoscopic evaluation revealed a mass occluding the right main bronchus and nodules in the left main bronchus.
- Initial biopsy showed chronic inflammation; subsequent biopsies confirmed malignant GCT, non-neural type (S-100 negative).
Findings:
- The case describes an extremely rare malignant pulmonary GCT.
- The tumor was S-100 negative, classifying it as a non-neural type.
- Advanced stage and contralateral spread precluded surgical resection.
Implications:
- This case underscores the diagnostic complexity of S-100 negative malignant pulmonary GCTs.
- Early and accurate diagnosis is crucial for appropriate management strategies.
- Further research is needed to understand the behavior and treatment of non-neural GCTs.
