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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.1K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Dec 29, 2025

Doppler Optical Coherence Tomography of Retinal Circulation
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Published on: September 18, 2012

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[Optical Coherence Tomography in Glaucomas: Tips and Tricks].

Christian Mardin

    Klinische Monatsblatter Fur Augenheilkunde
    |February 5, 2020
    PubMed
    Summary

    High-resolution optical coherence tomography (OCT) aids glaucoma diagnosis by measuring retinal layers and neuroretinal rim width. Careful OCT B-scan review is crucial to avoid misdiagnosis from artifacts or other conditions.

    Area of Science:

    • Ophthalmology
    • Medical Imaging
    • Glaucoma Diagnosis

    Background:

    • High-resolution optical coherence tomography (OCT) is vital for diagnosing glaucoma and monitoring disease progression.
    • OCT enables imaging and morphometry of the ganglion cell layer (GCL), retinal nerve fiber (RNF) layer thickness, and Bruch's membrane based minimum neuroretinal rim width (BMO-MRW).

    Purpose of the Study:

    • To highlight the diagnostic capabilities and potential pitfalls of OCT in glaucoma assessment.
    • To emphasize the importance of careful OCT B-scan inspection for accurate diagnosis and differentiation from other pathologies.

    Main Methods:

    • Utilizing spectral-domain or swept-source OCT techniques for high-resolution imaging.
    • Analyzing GCL and RNF layer thickness and BMO-MRW measurements.

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  • Comparing OCT findings with normative data and assessing B-scans for artifacts.

    • Main Results:

    • OCT measurements facilitate the detection of pathological changes and comparison with normative data.
    • False positive and false negative diagnoses can occur due to various artifacts and confounding conditions.
    • Conditions like epiretinal gliosis, AMD, cystoid changes, high myopia, neurological diseases, drusen, and disc edema can mimic or obscure glaucoma findings on OCT.

    Conclusions:

    • Accurate OCT glaucoma diagnosis requires high image quality and thorough knowledge of potential OCT pathologies and imaging techniques.
    • Careful inspection of OCT B-scans is mandatory to identify artifacts and differentiate glaucoma from other conditions.
    • Understanding the relationship between GCL, RNF, and BMO-MRW changes, alongside clinical correlation, is key to avoiding diagnostic pitfalls.