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Prolactin response to antipsychotics: An inpatient study
Liana Dehelean1, Ana-Maria Romosan1, Ion Papava1
1Neurosciences Department, Psychiatry Discipline, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Plos One
|February 5, 2020
Summary
Antipsychotic treatment impacts prolactin levels, with female patients and longer psychosis duration showing higher prolactin. Prolactin-sparing antipsychotics and longer psychosis duration over 10 years are linked to lower prolactin levels.
Area of Science:
- Psychiatry
- Endocrinology
Background:
- Antipsychotic medications are crucial for treating psychosis but can affect prolactin levels.
- Factors like gender, age, stress, and duration of psychosis influence these levels.
Purpose of the Study:
- To investigate prolactin level responses to antipsychotic treatment in acute psychosis patients.
- To analyze the influence of psychosis duration on prolactin response.
Main Methods:
- 170 acute schizophrenia and bipolar disorder patients were studied.
- Patients were grouped by psychosis duration (<5, 5-10, >10 years).
- Prolactin levels and symptom severity (using Brief Psychiatric Rating Scale) were measured.
Main Results:
- Hyperprolactinemia affected 70.6% of patients (66.7% female).
- Prolactin increased 2.46x in women and 1.59x in men.
- Female gender, antipsychotic potency, and psychosis duration >10 years significantly predicted prolactin levels.
Conclusions:
- Prolactin levels are influenced by patient gender, antipsychotic type, and psychosis duration.
- Female gender is associated with increased prolactin, while prolactin-sparing antipsychotics and longer psychosis duration correlate with lower levels.
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