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Ethical issues related to brain organoid research
Insoo Hyun1, J C Scharf-Deering1, Jeantine E Lunshof2
1Case Western Reserve University, USA.
Brain Research
|February 5, 2020
Summary
This review examines ethical challenges in human brain organoid research, covering oversight, consent, and moral status. Addressing these issues requires adapting existing stem cell research policies.
Area of Science:
- Neuroscience
- Bioethics
- Biotechnology
Background:
- Human brain organoids offer unprecedented models for studying brain development and disease.
- Rapid advancements necessitate a proactive examination of the ethical landscape surrounding this research.
Purpose of the Study:
- To review and categorize current ethical issues in human brain organoid research.
- To identify key stakeholders and their challenges in navigating these ethical considerations.
Main Methods:
- Literature review of ethical issues in human brain organoid research.
- Thematic analysis of identified ethical challenges.
Main Results:
- Key ethical themes include research oversight, biomaterial procurement, donor consent, translational delivery, animal research, and organoid consciousness/moral status.
- Each theme presents distinct challenges for researchers, bioethicists, regulators, institutions, and tissue banks.
Conclusions:
- Progress requires adapting established stem cell research ethics and policies to the unique aspects of brain organoid research.
- Collaborative efforts among stakeholders are crucial for responsible innovation in this field.
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