Diarylheptanoid: A privileged structure in drug discovery
De-Juan Sun1, Ling-Juan Zhu1, Yu-Qian Zhao1
1Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Wuya College of Innovation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Diarylheptanoids, found in turmeric spice, show diverse bioactivities and low toxicity. These compounds represent a privileged scaffold for developing new drugs in medicinal chemistry.
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Natural Products
Background:
- Privileged structures are crucial in drug design, offering effective templates.
- Diarylheptanoids, including curcumin from turmeric, exhibit significant bioactivity and low toxicity.
- Natural compounds like curcumin are increasingly explored for clinical applications.
Purpose of the Study:
- To highlight diarylheptanoids as a privileged scaffold in drug discovery.
- To review the diverse biological and pharmacological effects of diarylheptanoids.
- To explore therapeutic applications and dietary development based on diarylheptanoid structures.
Main Methods:
- Literature review of diarylheptanoids.
- Analysis of biological and pharmacological data.
- Exploration of structure-activity relationships.
Main Results:
- Diarylheptanoids possess a wide range of bioactivities.
- Curcumin, a prominent diarylheptanoid, demonstrates broad biological effects with low toxicity.
- The structural features of diarylheptanoids are amenable to drug development.
Conclusions:
- Diarylheptanoids serve as a valuable privileged scaffold for medicinal chemistry.
- Further research into diarylheptanoids can lead to novel therapeutic agents.
- Dietary sources of diarylheptanoids, like turmeric, offer potential health benefits.
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