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[Anorectal motility in systemic scleroderma]
1Universität Düsseldorf, Medizinische Klinik.
Zeitschrift Fur Gastroenterologie
|November 1, 1988
Summary
Systemic sclerosis significantly alters esophageal and anorectal motility. Esophageal and anorectal manometry effectively detect these differences, distinguishing patients from healthy individuals.
Area of Science:
- Gastroenterology
- Rheumatology
- Physiology
Context:
- Progressive systemic sclerosis (PSS) is a multisystem autoimmune disease.
- Gastrointestinal involvement, particularly esophageal and anorectal dysfunction, is common in PSS.
- Objective assessment of motility disturbances is crucial for understanding disease impact.
Purpose:
- To prospectively compare esophageal and anorectal motility in patients with PSS versus healthy controls.
- To evaluate the sensitivity of esophageal and anorectal manometry in identifying PSS-related motility abnormalities.
- To determine if manometry can differentiate PSS patients from normal subjects.
Summary:
- Seven patients with PSS underwent esophageal and anorectal manometry, compared to 22 and 9 healthy controls, respectively.
- Patients with PSS showed significant differences in lower esophageal sphincter (LES) function, including resting pressure, relaxation amplitude/duration, and incomplete relaxations.
- Anorectal motility alterations in PSS patients included decreased resting pressure, maximal squeeze pressure, and sphincter relaxation amplitude.
Impact:
- Esophageal and anorectal manometry are sensitive tools for detecting gastrointestinal motility disturbances in systemic sclerosis.
- These manometric findings can help differentiate PSS patients from healthy individuals.
- The study highlights the utility of manometry in assessing the gastrointestinal manifestations of systemic sclerosis.