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Cathelicidin LL-37 (an antimicrobial peptide)-induced colistin dependence in Acinetobacter baumannii
Ji-Young Lee1, Yoon-Kyoung Hong2, Kwan Soo Ko2
1Division of Antimicrobial Resistance, Korea Centers for Disease Control and Prevention, Cheongju 28159, South Korea.
Abstract:
In this study, we demonstrated the development of colistin dependence in Acinetobacter baumannii isolates after exposure to the human cationic antimicrobial peptide LL-37. The LL-37-induced colistin-dependent mutants showed susceptibility to many other antibiotics and IS1595 or ATTT insertions in LpxACD.
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