Related Experiment Video

Updated: Dec 29, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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Histone Demethylase JMJD1A Promotes Tumor Progression via Activating Snail in Prostate Cancer

Dong-E Tang1, Yong Dai1, Song-Hui Xu2,3

  • 1Department of Clinical Medical Research Center, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital Southern University of Science and Technology, Shenzhen People's Hospital, Shenzhen, Guangdong, P.R. China.

Molecular Cancer Research : MCR
|February 6, 2020
PubMed

Insights

The histone demethylase JMJD1A promotes prostate cancer progression by activating the Snail gene. Lowering JMJD1A levels could be a new therapeutic strategy for advanced prostate cancer.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Oncology

Background:

  • The histone demethylase JMJD1A regulates gene expression by removing methyl groups from H3K9.
  • JMJD1A is involved in spermatogenesis, stem cell renewal, and cancer.
  • The specific role of JMJD1A in prostate cancer progression is not well understood.

Purpose of the Study:

  • To investigate the role of JMJD1A in prostate cancer progression.
  • To elucidate the molecular mechanisms by which JMJD1A affects prostate cancer.

Main Methods:

  • Quantitative analysis of JMJD1A expression in prostate cancer tissues.
  • In vitro and in vivo experiments assessing the effects of JMJD1A overexpression and knockdown on cancer cell behavior.
  • Chromatin immunoprecipitation assays to determine JMJD1A's interaction with the Snail gene promoter.

Main Results:

  • JMJD1A expression is significantly elevated in prostate cancer tissues.
  • JMJD1A overexpression enhances prostate cancer cell proliferation, migration, invasion, and tumorigenesis.
  • JMJD1A directly binds to the Snail promoter, increasing its transcriptional activity via H3K9me1 and H3K9me2 demethylation.
  • JMJD1A knockdown reverses these effects.

Conclusions:

  • JMJD1A promotes prostate cancer progression by transcriptionally activating Snail.
  • JMJD1A is a potential therapeutic target for advanced prostate cancer.

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