Related Experiment Video
Updated: Dec 29, 2025

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
The synthesis and bioimaging of a biocompatible hydrogen sulfide fluorescent probe with high sensitivity and
Ruqiao Zhou1, Guiling Cui, Qingrong Qi
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China. yangli@scu.edu.cn.
Abstract:
Hydrogen sulfide (H2S), a well-known poisonous gas, has been recognized as a critical endogenous gas transmitter in the past decade. To provide a quick and efficient detection method for hydrogen sulfide, a novel fluorescent probe DCI-NCN was designed based on an isophoronitrile scaffold featured with the cyanoxy group as the detection group. DCI-NCN shows promising results including high selectivity, high sensitivity, good linear relationship and pH stability in vitro. In addition, good biosystem imaging performance of DCI-NCN is observed in Kunming mice.

