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Updated: Dec 29, 2025

Point-of-Care Lung Ultrasound in Adults: Image Acquisition
Published on: March 3, 2023
CEUS LI-RADS: a pictorial review
Tommaso Vincenzo Bartolotta1,2, Maria Chiara Terranova3, Cesare Gagliardo3
1BiND Department: Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, Via Del Vespro, 129 90127, Palermo, Italy. tommasovincenzo.bartolotta@unipa.it.
Contrast-enhanced ultrasound (CEUS) enhances liver lesion diagnosis in cirrhosis patients at risk for hepatocellular carcinoma (HCC). This pictorial essay details CEUS features of liver nodules using the CEUS Liver Imaging Reporting and Data System (LI-RADS) for accurate HCC diagnosis.
Area of Science:
- Radiology and Medical Imaging
- Hepatology
- Oncology
Background:
- Focal liver lesions (FLLs) in cirrhotic patients require accurate diagnosis to detect hepatocellular carcinoma (HCC).
- Contrast-enhanced ultrasound (CEUS) is a valuable tool recommended by international guidelines for evaluating FLLs in at-risk populations.
- Standardized reporting systems are crucial for consistent interpretation of imaging findings.
Purpose of the Study:
- To illustrate the characteristic features of liver nodules detected via CEUS in cirrhotic livers.
- To demonstrate the application of the CEUS Liver Imaging Reporting and Data System (LI-RADS) for classifying these nodules.
- To enhance diagnostic accuracy for hepatocellular carcinoma (HCC) in patients with cirrhosis.
Main Methods:
- A pictorial essay approach was used, presenting representative CEUS images of liver nodules.
- Nodules were categorized according to the established CEUS Liver Imaging Reporting and Data System (LI-RADS) criteria.
- Emphasis on visualizing and describing enhancement patterns and washout characteristics.
Main Results:
- CEUS demonstrated improved diagnostic performance in characterizing FLLs compared to conventional ultrasound.
- Specific CEUS LI-RADS categories were visually correlated with distinct imaging features of liver nodules.
- The study highlights key CEUS findings indicative of hepatocellular carcinoma (HCC) in cirrhotic livers.
Conclusions:
- CEUS, guided by LI-RADS, is an effective method for the diagnosis and characterization of FLLs in cirrhotic patients.
- Standardized reporting through CEUS LI-RADS facilitates accurate identification of hepatocellular carcinoma (HCC).
- This pictorial essay serves as a visual guide to CEUS features of liver nodules within the LI-RADS framework.
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