Relationships between recurrence patterns and subventricular zone involvement or CD133 expression in glioblastoma

Area of Science:

• Neuro-oncology
• Cancer biomarkers
• Glioblastoma multiforme (GBM) research

Background:

• Previous studies linked CD133 expression to glioblastoma (GBM) recurrence.
• Subventricular zone (SVZ) involvement is also suspected to correlate with distant GBM recurrence.

Purpose of the Study:

• To investigate the combined predictive value of SVZ involvement and CD133 expression for GBM recurrence patterns.
• To determine if integrated analysis improves prediction accuracy over individual factors.

Main Methods:

• Retrospective analysis of 167 GBM cases.
• Tumor classification into four groups based on MRI-defined spatial relationships with SVZ and cortex.
• Assessment of CD133 expression via immunohistochemistry.
• Evaluation of clinical and genetic factors, including age, KPS, Ki-67, surgery, IDH1, MGMT, and BRAF.

Main Results:

• Higher CD133 expression rates were observed in SVZ-positive tumors.
• Strong CD133 expression significantly correlated with shorter time to distant recurrence across multiple analyses.
• Distant recurrence was most frequent (70%) in GBM with SVZ-negative, cortex-positive classification and high CD133 expression (≥15%).

Conclusions:

• Integrated analysis of CD133 expression and MRI-based tumor classification is a promising tool for predicting GBM recurrence patterns.
• This combined approach may enhance prognostic accuracy for glioblastoma patients.