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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset

Laren Narapareddy1, Derek E Wildman2, Don L Armstrong3

  • 1Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia.

American Journal of Primatology
|February 6, 2020
PubMed

Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus, is a platyrrhine primate species that has provided much insight into studies of the primate placenta, maternal condition, and metabolic programming, yet the relationships between maternal weight and placental DNAm are unknown. Here, we report genome-wide DNAm from term marmoset placentas using reduced representation bisulfite sequencing. We identified 74 genes whose DNAm pattern is associated with maternal weight during gestation. These genes are predominantly involved in energy metabolism and homeostasis, including the regulation of glycolytic and lipid metabolic processes pathways.

Keywords:
developmental programmingepigeneticsmaternal metabolismnon-human primateobesity

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