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Inflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study

Lina Zhou1, Xiancang Ma1, Wei Wang1

  • 1Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.

Neuropsychiatric Disease and Treatment
|February 6, 2020
PubMed

Insights

Major depressive disorder (MDD) is linked to systemic inflammation, increasing coronary heart disease (CHD) risk. Elevated monocyte counts in MDD patients are a key predictor of this heightened CHD risk.

Area of Science:

  • Cardiovascular Medicine
  • Psychiatry
  • Immunology

Background:

  • Major depressive disorder (MDD) is associated with an increased risk of coronary heart disease (CHD).
  • The underlying mechanisms connecting MDD and elevated CHD risk are not fully understood.
  • Inflammation is implicated in the pathophysiology of both MDD and CHD.

Purpose of the Study:

  • To investigate the relationship between inflammatory biomarkers and CHD risk in patients diagnosed with MDD.
  • To explore whether markers of systemic inflammation are elevated in individuals with acute MDD.

Main Methods:

  • A cohort of 454 patients with acute MDD and 458 matched controls were analyzed.
  • Inflammation was assessed using complete blood count parameters, including platelet and monocyte counts.
  • Coronary heart disease (CHD) risk was evaluated using the Framingham risk score.

Main Results:

  • Patients with MDD exhibited signs of low-grade systemic inflammation, including elevated platelet and monocyte counts, and increased platelet/lymphocyte and monocyte/lymphocyte ratios.
  • A higher systemic immune-inflammation index was observed in the MDD group.
  • Monocyte count emerged as the sole significant predictor of CHD risk among patients with MDD.

Conclusions:

  • The findings support the concept of MDD as a systemic inflammatory condition.
  • Monocyte count serves as a valuable biomarker for predicting CHD risk in individuals with major depressive disorder.
Abstract

Keywords:
Framingham risk scorecomplete blood countcoronary heart diseaseinflammationmajor depressive disorder

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