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Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke

Chen Qin1, Xiuli Yan1, Hang Jin1

  • 1Department of Neurology, The First Hospital of Jilin University, Changchun 130021, People's Republic of China.

Neuropsychiatric Disease and Treatment
|February 6, 2020
PubMed

Insights

Remote ischemic conditioning (RIC) may improve cerebral blood flow (CBF) in ischemic stroke by enhancing cardiac function, collateral circulation, and neurovascular protection. Further research is needed to understand RIC mechanisms and clinical applications.

Area of Science:

  • Neuroscience
  • Cardiovascular Medicine
  • Cerebrovascular Diseases

Background:

  • Ischemic stroke is a leading cause of global disability, characterized by disrupted cerebral blood flow (CBF).
  • Maintaining adequate CBF, particularly in the acute phase, is critical for mitigating stroke severity and disability.
  • Remote ischemic conditioning (RIC) has shown therapeutic potential for ischemic stroke, but its mechanisms affecting CBF remain unclear.

Purpose of the Study:

  • To review and discuss potential mechanisms by which RIC influences cerebral hemodynamics in ischemic stroke.
  • To explore how RIC impacts factors such as cardiac function, collateral circulation, and neurovascular unit integrity.
  • To consolidate current understanding and identify future research directions for RIC in ischemic stroke treatment.

Main Methods:

  • Literature review of animal and clinical studies on remote ischemic conditioning (RIC) and ischemic stroke.
  • Analysis of proposed mechanisms including effects on cardiac function, cerebral collateral circulation, and neurovascular protection.
  • Examination of RIC's role in gas molecule formation and its impact on vascular endothelial and nervous system functions.

Main Results:

  • RIC demonstrates potential benefits for improving cerebral blood flow (CBF) in ischemic stroke models.
  • Proposed mechanisms involve enhanced cardiac output, improved collateral vessel function, and protection of the neurovascular unit.
  • RIC may also influence CBF through the production of gas molecules and modulation of vascular endothelial and neural pathways.

Conclusions:

  • Remote ischemic conditioning (RIC) presents a promising therapeutic strategy for enhancing cerebral blood flow (CBF) in ischemic stroke.
  • Understanding the multifaceted mechanisms of RIC is crucial for its effective clinical application.
  • Further research is warranted to fully elucidate RIC's effects and accelerate its translation into clinical practice for stroke management.

Keywords:
cerebral blood flowcerebral hemodynamicsischemic strokeremote ischemic conditioning

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