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Does the Autophagy Related Gene 7 (ATG7) Have a Role in Non-Melanoma Skin Cancer?
Rehab M Samaka1, Mohammed A Basha2, Eman Mansour3
1Pathology Department, Faculty of Medicine, Menoufia University, Al Minufya, Egypt.
Purpose:
To evaluate the role of autophagy related gene 7 (ATG7) in non-melanoma skin cancer.
Subjects And Methods:
This retrospective and prospective case-control study was performed on 104 patients with non-melanoma skin cancer (NMSC) in addition to 20 apparently healthy subjects matched for age and sex as a control group. Multiple skin biopsies were taken for immunohistochemical evaluation of ATG7 expression.
Results:
Both epithelial and stromal ATG7 were expressed in all participants while all patients showed nucleocytoplasmic localization and controls showed both cytoplasmic and nucleocytoplasmic expression. In addition, significantly higher H-scores of ATG7 in both epithelium and stroma were detected in patients compared to controls (P<0.001).
Conclusion:
ATG7 nucleocytoplasmic topographic localization might be involved in the pathogenesis of NMSC, which can open the gate for new target therapy for this skin cancer.
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