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Paronychia and Periungual Granulation as a Novel Side Effect of Ibrutinib: A Case Report

Ahu Yorulmaz1, Basak Yalcin1

  • 1Department of Dermatology, Ankara Bilkent City Hospital, Ankara, Turkey.

Skin Appendage Disorders
|February 6, 2020
PubMed

Ibrutinib is an oral covalent inhibitor of the Bruton's tyrosine kinase pathway and is approved for the treatment of B-cell malignancies including chronic lymphocytic leukaemia, mantle cell lymphoma, and Waldenström's macroglobulinaemia. It is generally a drug of choice for high-risk patients with indolent lymphomas. The safety profile of ibrutinib appears to be tolerable, with well-known side effects such as infections and haematologic complications. Additionally, dermatological adverse reactions with ibrutinib therapy have been reported to encompass maculopapular rash and hair/nail abnormalities. Here, we present a case of ibrutinib-induced paronychia and periungual granulation in a 40-year-old woman. To the best of our knowledge, this is the third description of ibrutinib-induced paronychia and periungual granulation.

Keywords:
IbrutinibParonychiaPeriungual granulationSide effect

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