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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
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Progress in understanding the relationship between long noncoding RNA and endometriosis.

Wenying Yan1, Hongmei Hu2, Biao Tang2

  • 1Department of Gynecology, Wangjiang Hospital, Sichuan University, China, No. 24, South Section of First Ring Road, Chengdu City, Sichuan Province, China.

European Journal of Obstetrics & Gynecology and Reproductive Biology: X
|February 6, 2020
PubMed
Summary

Long-chain non-coding RNAs (lncRNAs) are increasingly linked to endometriosis, a common gynecological disease. Research explores lncRNAs' role in endometriosis pathogenesis, offering new insights into its genetic basis.

Keywords:
CDK6, cyclin dependent kinase 6EMs, EndometriosisEarly diagnosisEndometriosisHIF-1α, Hypoxia inducible factor-1alphaIgf1r, insulin-like growth factor-1 receptorIgf2, insulin-like growth factor 2NATs, natural antisense transcriptsNon-coding RNASRA, Steroid receptor RNA activatorSRAP, steroid receptor activator proteinlncRNAslncRNAs, long non-coding RNAsncRNAs, non-coding RNAspiRNAs, PIWI-interacting RNAssiRNAs, short inhibitory RNAssnRNAs, small nuclear RNAs

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Area of Science:

  • Genomics
  • Molecular Biology
  • Gynecology

Background:

  • Endometriosis is a prevalent gynecological condition with an unclear etiology.
  • Current theories do not fully explain the pathogenesis of endometriosis.
  • Genetics is increasingly implicated in the development of endometriosis.

Purpose of the Study:

  • To review the current research progress on long-chain non-coding RNAs (lncRNAs) in relation to endometriosis.
  • To explore the potential role of lncRNAs in the pathogenesis of endometriosis.
  • To provide insights for future research into endometriosis etiology.

Main Methods:

  • Literature review of studies investigating lncRNAs and endometriosis.
  • Analysis of the biological functions of lncRNAs in disease progression.
  • Synthesis of current understanding of lncRNA involvement in endometriosis.

Main Results:

  • lncRNAs are non-protein-coding RNA molecules with significant biological functions.
  • lncRNAs play a role in both normal individual development and disease progression.
  • Emerging research suggests a connection between lncRNAs and the occurrence/development of endometriosis.

Conclusions:

  • lncRNAs represent a significant area of medical research with potential relevance to endometriosis.
  • Further investigation into lncRNAs may elucidate the complex pathogenesis of endometriosis.
  • Understanding lncRNA functions could offer novel therapeutic targets for endometriosis.