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Related Experiment Videos

Stretch-induced contraction in pulmonary arteries.

T J Kulik1, J N Evans, W J Gamble

  • 1Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

The American Journal of Physiology
|December 1, 1988
PubMed
Summary

Small feline pulmonary arteries contract when stretched, influencing pulmonary vascular tone. This stretch-induced contraction requires calcium and is sensitive to diltiazem, but not alpha-adrenergic or endothelial factors.

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Area of Science:

  • Physiology
  • Vascular Biology
  • Smooth Muscle Physiology

Background:

  • Systemic blood vessels contract in response to stretch.
  • The effect of stretch on pulmonary vessels is not well-described.

Purpose of the Study:

  • To investigate whether pulmonary arteries contract when subjected to mechanical stretch.
  • To characterize the nature of stretch-induced responses in feline pulmonary arteries.

Main Methods:

  • Isolated small and large feline pulmonary artery segments were stretched in vitro.
  • Active force generation in response to stretch was measured.
  • Pharmacological agents (diltiazem, indomethacin, etc.) and calcium were used to probe the mechanisms.

Main Results:

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  • 89% of small pulmonary artery segments (diameter < 1000 microns) contracted upon stretching.
  • Contraction magnitude correlated with stretch magnitude in 65% of responsive segments.
  • Large pulmonary arteries (diameter >= 1000 microns) did not exhibit stretch-induced contraction.
  • Stretch-induced contraction was calcium-dependent and inhibited by diltiazem.
  • Repeated stretching led to diminished force development.

Conclusions:

  • Mechanical stretch can directly induce contraction in smooth muscle of small feline pulmonary arteries.
  • Stretch may be a significant factor in regulating pulmonary vascular tone.
  • Feline pulmonary arteries serve as a viable model for studying stretch-induced vascular contraction.