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Updated: Dec 29, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Electrochemical dehydrogenative cross-coupling of two anilines: facile synthesis of unsymmetrical biaryls
Mu-Jia Luo1, Yang Li, Xuan-Hui Ouyang
1State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China. liyang8825490@126.com jhli@hnu.edu.cn delianghe@hnu.edu.cn.
Abstract:
A new, general ortho/para-selective anodic dehydrogenative cross-coupling of two aryl amines, naphthalen-2-amine derivatives and anilines, is described. This electrochemical protocol assembles a wide range of unsymmetrical biaryls in good to excellent yields under mild, additional-metal-catalyst-free, oxidant-free conditions with excellent selectivity, broad substrate scope, and wide functional group tolerance. This electrochemical technology is highlighted with facile incorporation of important pharmacophores into the resulting biaryls, and is applicable to the homocoupling of anilines for producing symmetrical biaryls.
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