Related Experiment Video
Updated: Dec 29, 2025

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
Published on: January 27, 2013
A selective "turn-on" sensor for recognizing In3+ and Zn2+ in respective systems based on imidazo[2,1-b]thiazole
Yuankang Xu1, Songfang Zhao, Yanxia Zhang
1School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China. chm_zhanggy@ujn.edu.cn.
Abstract:
A new simple and easily synthesized multitarget sensor, (E)-N'-(4-(diethylamino)-2-hydroxybenzylidene)imidazo[2,1-b]thiazole-6-carbohydrazide (X), was designed and synthesized using imidazo[2,1-b]thiazole-6-carboxylic acid and 4-(diethylamino)-2-hydroxybenzaldehyde. X could be used as a sensor to detect In3+ in DMF-H2O buffer solution and detect Zn2+ in EtOH-H2O buffer solution through fluorescence enhancement with detection limits of 1.02 × 10-9 M and 5.5 × 10-9 M, respectively. X exhibited an efficient "off-on-off" fluorescence behavior by cyclic addition of metal ions (In3+ and Zn2+) and EDTA. The stoichiometry between X and metal ions (In3+ and Zn2+) was 1 : 1. The binding mode and sensing mechanism of X with metal ions (In3+ and Zn2+) was verified by theoretical calculations using Gaussian 09 based on B3LYP/6-31G(d) and B3LYP/LANL2DZ basis, respectively. Moreover, X could be applied as a potential sensor for the quantitative detection of In3+ and Zn2+ with a satisfactory recovery and relative standard deviation (RSD) in real water samples.
Related Concept Videos
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

