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Aptamer-based nanostructured interfaces for the detection and release of circulating tumor cells
1CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China. nsun2013@sinano.ac.cn rjpei2011@sinano.ac.cn.
Journal of Materials Chemistry. B
|February 6, 2020
Summary
Detecting rare circulating tumor cells (CTCs) is crucial for cancer care. Aptamer-functionalized nanostructured interfaces offer a promising strategy for sensitive CTC detection and non-damaging release.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Circulating tumor cells (CTCs) provide vital clinical information for cancer diagnosis, prognosis, and treatment monitoring.
- The extreme rarity of CTCs in patient blood presents significant challenges for their isolation and analysis.
- Current CTC detection methods face limitations in capture efficiency and specificity.
Purpose of the Study:
- To review advancements in the detection and release of circulating tumor cells (CTCs).
- To highlight the application of aptamer-functionalized nanostructured interfaces as platforms for CTC analysis.
- To discuss the advantages of aptamers in CTC capture and release strategies.
Main Methods:
- Utilizing nanostructured interfaces for enhanced CTC capture.
- Employing aptamers for specific and high-affinity binding of CTCs.
- Investigating aptamer-mediated methods for non-destructive CTC release under mild conditions.
Main Results:
- Nanostructured interfaces improve CTC capture efficiency by overcoming current limitations.
- Aptamers demonstrate excellent affinity, stability, and low immunogenicity for CTC detection.
- Aptamer-mediated methods enable effective and gentle release of captured CTCs.
Conclusions:
- Aptamer-functionalized nanostructured interfaces represent a powerful platform for CTC detection and analysis.
- These advanced methods hold significant potential for improving cancer diagnosis, prognosis, and personalized therapy.
- Further development in this area can overcome current challenges in CTC isolation and characterization.
