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New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
Clóvis Ney Pinheiro Macêdo1, Francisco Evanilso Silva Braga2, Ana Paula Bomfim Soares Campelo3
1Fellow Master degree, Postgraduate Program in Minimally Invasive Technology and Health Simulation Area, Medical School, Centro Universitário Christus (UNICHRISTUS), Fortaleza-CE, Brazil. Conception and design of the study, technical procedures, acquisition and interpretation of data, manuscript preparation, critical revision.
Purpose:
To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam).
Methods:
Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals.
Results:
At the histological examination, all animals (six animals - 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05).
Conclusion:
Rut-bpy may prevent renal histological changes in rats caused by meloxicam.
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