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Updated: Dec 29, 2025

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Rational Design of an Iron-Based Catalyst for Suzuki-Miyaura Cross-Couplings Involving Heteroaromatic Boronic Esters
Michael P Crockett1, Alexander S Wong1, Bo Li1
1Department of Chemistry, Boston College, Merkert Chemistry Center, 2609 Beacon St., Chestnut Hill, MA, 02467, USA.
Abstract:
Suzuki-Miyaura cross-coupling reactions between a variety of alkyl halides and unactivated aryl boronic esters using a rationally designed iron-based catalyst supported by β-diketiminate ligands are described. High catalyst activity resulted in a broad substrate scope that included tertiary alkyl halides and heteroaromatic boronic esters. Mechanistic experiments revealed that the iron-based catalyst benefited from the propensity for β-diketiminate ligands to support low-coordinate and highly reducing iron amide intermediates, which are very efficient for effecting the transmetalation step required for the Suzuki-Miyaura cross-coupling reaction.
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