Related Experiment Video
Updated: Dec 29, 2025

Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
Published on: March 28, 2025
Reducing the Pain Behind Opioid Prescribing in Primary Care
José Luis González1,2,3, Radhika Prabhakar1,2, Jennifer Marks1,2
1University of Southern California, Los Angeles, California.
A comprehensive initiative significantly reduced opioid prescribing in an internal medicine resident clinic. This approach led to substantial decreases in opioid prescriptions and morphine milligram equivalents (MMEs), offering a model for safe prescribing practices.
Area of Science:
- Internal Medicine
- Pain Management
- Public Health
Background:
- Opioid prescribing in resident clinics requires effective strategies for reduction.
- Long-term opioid therapy (LTOT) management presents unique challenges in primary care settings.
Purpose of the Study:
- To evaluate the efficacy of a multifaceted intervention designed to decrease opioid prescribing within an internal medicine resident clinic.
- To assess the impact of the initiative on prescription volume, patient numbers, and morphine milligram equivalents (MMEs).
Main Methods:
- Retrospective observational study analyzing pharmacy dispensing data from July 2016 to July 2018.
- Implementation of interventions including resident education, specialized faculty supervision for LTOT, and promotion of alternative pain management modalities.
- Calculation of changes in opioid prescriptions, patient recipients, total MMEs, and average per-patient daily MMEs.
Main Results:
- Observed an average monthly reduction of 2.44% in opioid prescriptions and 1.83% in patients receiving them.
- Achieved a 74.3% reduction in total MMEs and a 66.5% reduction in average per-patient daily MMEs over two years.
- Demonstrated a nearly threefold decrease in opioid prescribing compared to national trends.
Conclusions:
- A comprehensive initiative effectively reduced opioid prescribing in a primary care resident clinic.
- The findings provide valuable insights for other academic medical centers aiming to improve opioid prescribing safety.
- The study highlights the potential for significant reductions in high-dose opioid prescribing through targeted interventions.
Related Concept Videos
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Opioid Analgesics: Morphine and Other Natural Cogeners
Opioid Receptors: Overview
Nociception
Pain

