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Nutritive vitamins as epidrugs.
Suza Mohammad Nur1, Suvasmita Rath2, Varish Ahmad3
1Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Critical Reviews in Food Science and Nutrition
|February 6, 2020
Summary
Vitamins significantly influence the epigenome, impacting DNA, RNA, and histone modifications. Further research is needed to fully understand these vitamin-mediated epigenetic regulations for potential therapeutic applications.
Area of Science:
- Epigenetics
- Nutritional Science
- Molecular Biology
Background:
- Epigenetic modifications are crucial in disease development.
- Diet and lifestyle factors influence the epigenome.
- Vitamins are key dietary nutrients impacting epigenetic processes.
Purpose of the Study:
- To review the role of vitamins as epigenetic modifiers.
- To highlight evidence for vitamins as potential epidrugs.
- To identify gaps in understanding vitamin-mediated epigenetic regulation.
Main Methods:
- Literature review of existing studies on vitamins and epigenetics.
- Analysis of vitamin roles in DNA, RNA, and histone modifications.
- Examination of vitamin influence on non-coding RNA expression.
Main Results:
- Vitamin A regulates major epigenetic mechanisms.
- B group vitamins (biotin, niacin, pantothenic acid) modulate the epigenome.
- Vitamins C and D influence DNA methylation, histone modifications, and miRNA pathways.
Conclusions:
- Vitamins act as significant epigenetic modifiers.
- Detailed mechanisms of vitamin-mediated epigenetic regulation require further investigation.
- Vitamins show promise as potential epidrugs for disease management.
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