Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.2K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.2K
Immunological Memory01:23

Immunological Memory

14.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.7K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

15.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.7K
Humoral Immune Responses01:36

Humoral Immune Responses

83.1K
Overview
83.1K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

2.8K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.8K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.1K
Overview
83.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytokine-based strategies to improve prognostic enrichment of pediatric ARDS.

Critical care (London, England)·2026
Same author

Jump-starting the T cell response in established tumors.

bioRxiv : the preprint server for biology·2026
Same author

SAHA Alters Macrophages in the Tumor-Immune Landscape in Preclinical Models of Triple-Negative Breast Cancer.

Pharmaceutics·2026
Same author

Intranasal Immunization with Live-Attenuated RSV-Vectored SARS-CoV-2 Vaccines Elicits Antigen-Specific Systemic and Mucosal Immunity and Protects Against Viral Challenge and Natural Infection.

Vaccines·2026
Same author

Transcriptional programming of early-forming memory B cells arises independently of cognate CD4+ T-cell interactions.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

An "old" cytokine's new trick: IL-1β in B cells and the germinal center.

Function (Oxford, England)·2026
Same journal

Reovirus Reassortants Reveal Context-Dependent Oncolytic Phenotypes Across Epithelial Cancer Cell Lines.

Viral immunology·2026
Same journal

Syncytia Formation in the Pathogenesis of SARS-CoV-2 Infection: Lessons from Viral Infections.

Viral immunology·2026
Same journal

Screening and Characterization of Nanobody Against the Emerging Dairy Cattle H5N1 Influenza Virus.

Viral immunology·2026
Same journal

Immunoinformatics-Driven Design of a Multiepitope Vaccine for Rustrela Virus-Induced Neurological Diseases: A New Frontier in Encephalitis and Meningoencephalitis Prevention.

Viral immunology·2026
Same journal

Single-Cell Transcriptomic Profiling Reveals Molecular Alterations in the Airway Epithelial Cells of Children with Wheezing Infected by Respiratory Syncytial Virus.

Viral immunology·2026
Same journal

Effect of Pentoxifylline on Inflammatory Markers in COVID-19: A Meta-Analysis of Randomized Controlled Trials.

Viral immunology·2026
See all related articles

Related Experiment Video

Updated: Dec 29, 2025

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
08:26

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

15.8K

Resident Memory B Cells.

S Rameeza Allie1, Troy D Randall1

  • 1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Viral Immunology
|February 6, 2020
PubMed
Summary
This summary is machine-generated.

This study characterizes tissue-resident memory B (BRM) cells, which reside in non-lymphoid tissues and provide rapid, localized immune protection. Understanding BRM cells is crucial for developing targeted immunotherapies.

Keywords:
memory B cellmucosal immunitytissue-resident memorytissue-specific immunity

More Related Videos

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

12.9K
Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

7.2K

Related Experiment Videos

Last Updated: Dec 29, 2025

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity
08:26

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

15.8K
In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

12.9K
Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

7.2K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Adaptive immunity relies on diverse naive lymphocytes that recirculate through lymphoid organs.
  • Antigen exposure induces lymphocyte expansion, differentiation, and memory cell formation.
  • Tissue-resident memory cells remain in non-lymphoid tissues for rapid local responses.

Purpose of the Study:

  • To characterize memory B cells in various locations.
  • To investigate their potential as tissue-resident memory B (BRM) cells.
  • To discuss their roles in immunity and homeostasis.

Main Methods:

  • Analysis of memory B cell characteristics in different tissues.
  • Evaluation of their potential to function as bona fide BRM cells.

Main Results:

  • Antigen-experienced B cells are found in abundance at barrier surfaces.
  • The characterization of these cells as tissue-resident memory B (BRM) cells is underdeveloped.
  • This study provides insights into the characteristics of these cells.

Conclusions:

  • Tissue-resident memory B (BRM) cells are a distinct subset of memory B cells.
  • They reside in non-lymphoid tissues and contribute to localized immunity.
  • Further research is needed to fully understand their functions in immunity and homeostasis.