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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Inheritance of Chromatin Structures03:17

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Related Experiment Video

Updated: Dec 29, 2025

An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila
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Alcohol Makes Its Epigenetic Marks.

Subhash C Pandey1, John Peyton Bohnsack2

  • 1Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA; Jesse Brown VA Medical Center, Chicago, IL 60612, USA.

Cell Metabolism
|February 6, 2020
PubMed
Summary
This summary is machine-generated.

Alcohol metabolism in the liver produces acetyl-CoA, which epigenetically regulates ethanol's brain effects. This occurs through a process called histone acetylation, impacting how the brain responds to alcohol.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Epigenetics

Background:

  • Alcohol consumption leads to toxic effects mediated by liver metabolism into acetaldehyde, acetate, and acetyl-CoA.
  • The epigenetic mechanisms underlying alcohol's effects on the brain are not fully understood.

Purpose of the Study:

  • To investigate the epigenetic role of alcohol-derived acetyl-CoA in the brain.
  • To elucidate the mechanism by which ethanol affects the brain through histone acetylation.

Main Methods:

  • Utilized findings from Mews et al. (2019) published in Nature.
  • Focused on the metabolic pathway of alcohol and its downstream metabolite, acetyl-CoA.

Main Results:

  • Alcohol-derived acetyl-CoA plays a significant epigenetic role in the brain.
  • Ethanol's effects on the brain are regulated through histone acetylation mediated by acetyl-CoA.

Conclusions:

  • Alcohol metabolism generates acetyl-CoA that influences brain function epigenetically.
  • Histone acetylation is a key mechanism linking alcohol consumption to its neurological effects.