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Ovarian Seromucinous Tumors: Pathogenesis, Morphologic Spectrum, and Clinical Issues
Michiko Nagamine1, Yoshiki Mikami2
1Department of Pathology, Japanese Red Cross Kumamoto Hospital, Japan.
Diagnostics (Basel, Switzerland)
|February 7, 2020
Summary
Ovarian seromucinous tumors, a distinct type of ovarian neoplasm, are frequently linked to endometriosis. This review clarifies their clinicopathological features and addresses diagnostic challenges for pathologists and clinicians.
Area of Science:
- Gynecologic Pathology
- Oncology
- Epithelial Tumors
Background:
- Ovarian seromucinous tumors were classified by the World Health Organization in 2014.
- These neoplasms often present bilaterally and are associated with endometriosis.
- They exhibit papillary architecture and diverse müllerian-type epithelium.
Purpose of the Study:
- To review the clinicopathological characteristics of benign, borderline, and malignant seromucinous tumors.
- To address the confusion arising from nomenclature, definition, and morphological discrepancies.
- To clarify the relationship of seromucinous tumors to endometriosis-related ovarian neoplasms.
Main Methods:
- Literature review of clinicopathological studies.
- Analysis of World Health Organization classification criteria.
- Summary of molecular studies on ovarian neoplasms.
Main Results:
- Seromucinous tumors are considered endometriosis-related, potentially as a variant of endometrioid tumors.
- Frequent association with endometriosis and bilaterality are key features.
- Morphological diversity and classification issues cause diagnostic challenges.
Conclusions:
- Clarification of seromucinous tumor features is essential for accurate diagnosis.
- Further research may resolve controversies regarding their classification and relationship to endometrioid tumors.
- Standardized diagnostic criteria are needed for clinicians and pathologists.
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