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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Published on: June 16, 2014

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Epicardial Adipose Tissue, Adiponectin and Leptin: A Potential Source of Cardiovascular Risk in Chronic Kidney

Luis D'Marco1, Maria Jesús Puchades1, Jose Luis Gorriz1

  • 1Nephrology Department, Hospital Clínico Universitario, INCLIVA, University of Valencia, 46010 Valencia, Spain.

International Journal of Molecular Sciences
|February 7, 2020
PubMed

Insights

Epicardial adipose tissue (EAT) significantly impacts cardiovascular disease risk, especially in chronic kidney disease (CKD) patients. EAT influences atherosclerosis via adipokines like adiponectin and leptin, highlighting its role in cardiometabolic health.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Cardiovascular disease (CVD) is highly prevalent in chronic kidney disease (CKD) patients.
  • Factors beyond diabetes and metabolic syndrome contribute to this increased CVD risk.
  • Visceral adipose tissue, particularly epicardial adipose tissue (EAT), is implicated in atherosclerosis.

Purpose of the Study:

  • To review the impact of EAT on cardiovascular outcomes.
  • To explore EAT's role in both the general population and CKD patients.
  • To examine adiponectin and leptin as mediators of EAT-associated cardiovascular risk.

Main Methods:

  • Literature review of current knowledge on EAT and cardiovascular outcomes.
  • Focus on studies investigating EAT in general and CKD populations.
  • Analysis of adipocytokines (adiponectin, leptin) secreted by EAT.

Main Results:

  • EAT is increasingly recognized as a significant cardiometabolic factor.
  • EAT influences atherosclerosis through paracrine and endocrine pathways.
  • Adiponectin and leptin are key adipocytokines involved in EAT's effects.

Conclusions:

  • EAT plays a crucial role in promoting atherosclerosis and cardiovascular complications.
  • EAT's impact is particularly relevant in the context of chronic kidney disease.
  • Adiponectin and leptin are potential mediators linking EAT to elevated cardiovascular risk.

Keywords:
Adiponectincardiovascular diseaseepicardial adipose tissueleptin

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