Related Experiment Video
Updated: Dec 29, 2025

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Subdivision of modified-release tablets: state-of-the-art and future perspectives
Marcilio Cunha-Filho1, Guilherme M Gelfuso1, Tais Gratieri1
1Laboratory of Food, Drugs, & Cosmetics (LTMAC), University of Brasília (UnB), 70910-900, Brasília, DF, Brazil.
Abstract:
Tablet splitting is a practice disseminated among health professionals for dose adjustments, swallowing facilitation or even treatment cost reduction. Nevertheless, tablets not designed for this purpose cause imprecise dosage and stability loss with important therapeutic repercussions. Novel technologies of modified drug release tablets have come to market including new materials and innovative production processes, for example, polymeric matrix, orodispersible, 3D printing, MUPs, etc. The heterogeneity and complexity of these tablets go well beyond a traditional gastroresistant coating tablet, making orientations on the practice of tablet subdivision difficult. This editorial aims to provide a critical and up-to-date evaluation of this scenario based on the most recent studies involving the subdivision of modified-release tablets.
More Related Videos
11:27A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
07:42Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
Published on: March 1, 2024
Related Concept Videos
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Factors Influencing Drug Absorption: Pharmaceutical Parameters
FDA Approved Drugs: Changes to Approved Drugs
Factors Affecting Dissolution: Particle Size and Effective Surface Area