Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reflex decrease of histamine-induced bronchoconstriction after laryngeal stimulation in asthmatic patients.

M C Michoud1, A Jeanneret-Grosjean, A Cohen

  • 1Department of Medicine, Hôtel-Dieu Hospital, Université de Montréal, Canada.

The American Review of Respiratory Disease
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

tDNA(ser) sequences are involved in the excision of Streptomyces griseus plasmid pSG1.

Gene·1992
Same author

Expression of cytokines and their receptors by human thymocytes and thymic stromal cells.

Immunology·1992
Same author

Conservative surgery and radiation therapy for intraductal carcinoma of the breast.

The Journal of the Florida Medical Association·1992
Same author

Asymmetry in visual search for targets defined by differences in movement speed.

Journal of experimental psychology. Human perception and performance·1992
Same author

Clinical decision making for discharge planning in a changing psychiatric environment.

Health & social work·1992
Same author

Immunization of colorectal cancer patients with modified ovine submaxillary gland mucin and adjuvants induces IgM and IgG antibodies to sialylated Tn.

Cancer research·1992
Same journal

Human lung lysozyme: sources and properties.

The American review of respiratory disease·2015
Same journal

"Immotile-cilia" syndrome and ciliary abnormalities induced by infection and injury.

The American review of respiratory disease·2013
Same journal

Adult criteria for obstructive apnea do not identify children with serious obstruction.

The American review of respiratory disease·1993
Same journal

Cell adhesion molecules and the bronchial epithelium.

The American review of respiratory disease·1993
Same journal

Adhesion molecules and cytokine production.

The American review of respiratory disease·1993
Same journal

Molecular mechanisms mediating lymphocyte recirculation, inflammation, and metastasis formation.

The American review of respiratory disease·1993
See all related articles

Stimulating vocal cords in asthma patients reflexively reduces bronchoconstriction via the nonadrenergic noncholinergic nervous system. This finding offers new insights into asthma management and respiratory reflex pathways.

Area of Science:

  • Respiratory Medicine
  • Neuroscience
  • Pulmonology

Background:

  • Asthma involves airway hyperresponsiveness.
  • The nonadrenergic noncholinergic (NAN C) nervous system plays a role in airway tone.
  • Reflex activation of NAN C pathways in asthma is not fully understood.

Purpose of the Study:

  • To investigate if vocal cord stimulation can reflexively activate the NAN C nervous system in asthmatic patients.
  • To determine the effect of vocal cord stimulation on histamine-induced bronchoconstriction.
  • To assess the role of circulating catecholamines in this reflex response.

Main Methods:

  • Subjects (asthmatic patients) underwent transnasal bronchoscopy.
  • Vocal cord stimulation was performed using a cytology brush.

Related Experiment Videos

  • Cholinergic blockers were administered, and bronchoconstriction was induced with histamine.
  • Pulmonary resistance (RL) and plasma catecholamine levels were measured before and after stimulation.

    • Main Results:

    • Vocal cord stimulation significantly decreased RL in asthmatic patients (p < 0.01).
    • Pulmonary resistance decreased post-stimulation, indicating reduced bronchoconstriction (p < 0.05).
    • Plasma epinephrine and norepinephrine levels showed non-significant increases, suggesting a limited role of circulating catecholamines.

    Conclusions:

    • Vocal cord stimulation elicits a reflex decrease in bronchoconstriction in asthmatic patients.
    • This reflex is mediated, in part, by the nonadrenergic noncholinergic nervous system.
    • The findings suggest potential therapeutic modulation of asthma through airway reflexes.