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Utilization, effectiveness, and safety of tranexamic acid use in hip fracture surgery: A population-based study
Zoe B Cheung1, Shawn G Anthony1, David A Forsh1
1Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai Health System, New York, NY, USA.
Objective:
To assess the effect of tranexamic acid (TXA) use in hip fracture surgery.
Methods:
A retrospective cohort study was performed using the Premier Healthcare database. A propensity score matching approach was applied to assess associations between TXA use and blood transfusion, perioperative complications, length of stay (LOS), and hospitalization cost.
Results:
In 153,169 patients, TXA use was associated with a 17% decrease in odds of blood transfusion, no increase in the risk of perioperative complications, 16% shorter LOS, and minimal effects on hospitalization cost.
Conclusion:
Our results are in support of a wider use of TXA in hip fracture surgery.
Level Of Evidence:
Level III.
