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Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
Published on: March 19, 2018
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Retendo (mucopolygen complex) effects on achille tendon healing
H Ozan Turkmen1, Ali Murat Kalender2, Sezgin Bahadır Tekin1
1Dr. Ersin Arslan Education and Research Hospital Gaziantep, Turkey.
Journal of Orthopaedics
|February 7, 2020
Summary
Retendon (mucopolygen complex) improved collagen sequencing in Achilles tendon healing histologically but did not significantly enhance biomechanical strength in rat models. Further research is needed to understand its full effect mechanism.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Orthopedic Research
Background:
- Achilles tendon injuries present significant recovery challenges with current treatments.
- Limited efficacy of existing surgical procedures leads to re-rupture and prolonged recovery times.
- Physiological recovery and early ankle mobility remain problematic after Achilles tendon injuries.
Purpose of the Study:
- To investigate the recovery effects of Retendon (mucopolygen complex) on Achilles tendon healing.
- To evaluate the histological and biomechanical impact of Retendon on injured Achilles tendons.
- To elucidate the mechanism of action for Retendon in tendon repair.
Main Methods:
- A study involving 40 female Wistar-Albino rats divided into experimental and control groups.
- The experimental group received Retendon (Mucopolysaccharides, Hydrolyzed Collagen Type I, Vitamin C).
- Histological and biomechanical analyses were performed to assess tendon recovery.
Main Results:
- Histological examination revealed more regular collagen formation in the Retendon group compared to the control.
- No significant differences were observed in vascularization, inflammation, or fibroblastic levels.
- Biomechanical testing showed no significant improvement in the mean load tolerance of the Achilles tendon.
Conclusions:
- Retendon (mucopolygen complex) positively influences collagen sequencing during Achilles tendon healing at a histological level.
- The study did not find significant biomechanical benefits in terms of load-bearing capacity.
- The precise mechanism of Retendon in tendon diseases requires further investigation.
