Immunological microenvironment gene expression in patients with diffuse large B cell non Hodgkin lymphoma

Area of Science:

• Immunology
• Oncology
• Molecular Biology

Background:

• Non-Hodgkin lymphoma (NHL) is a cancer of the immune system.
• Deregulation of cellular pathways drives lymphoma occurrence and progression.
• Understanding immune system genetics is key to lymphoma etiology.

Purpose of the Study:

• To evaluate the expression of five immune-related genes: PD-1, FOXP3, GrA, GrB, and CD11c.
• To assess these gene expressions in patients diagnosed with diffuse large B cell non-Hodgkin lymphoma (DLBCL).

Main Methods:

• Study included 50 DLBCL patients and 50 healthy controls.
• Laboratory tests included complete blood count, serum lactate dehydrogenase, and β2-microglobulin levels.
• Gene expression levels of PD-1, FOXP3, GrA, GrB, and CD11c were determined.

Main Results:

• PD-1, FOXP3, GrA, GrB, and CD11c gene expressions were significantly higher in DLBCL patients compared to controls.
• Elevated gene expression levels were observed in the studied DLBCL cohort.

Conclusions:

• DLBCL patients exhibit variable expression levels of PD-1, FOXP3, GrA, GrB, and CD11c.
• These gene expression levels correlate with overall survival (OS) in DLBCL patients.
• The studied immune-related genes show potential as predictors of outcome in DLBCL.