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Nausea and Vomiting in Advanced Cancer
1Department of Hematology/Oncology, University of Alabama Birmingham, UAB Comprehensive Cancer Center, 1802 Sixth Avenue, North Pavilion 2540K, Birmingham, AL, 35294, USA. rnavari@uabmc.edu.
Current Treatment Options in Oncology
|February 7, 2020
Summary
Olanzapine shows promise in managing nausea and vomiting in advanced cancer patients. This includes prevention and treatment of chemotherapy-induced symptoms and chronic nausea unrelated to cancer treatment.
Area of Science:
- Oncology
- Palliative Care
- Pharmacology
Background:
- Nausea and vomiting are prevalent in advanced cancer patients, stemming from treatments or the disease itself.
- Current antiemetic guidelines effectively prevent chemotherapy-induced nausea and vomiting (CINV) but are less successful in treating established symptoms.
- Chronic nausea and vomiting unrelated to treatment present a significant clinical challenge with limited effective interventions.
Purpose of the Study:
- To evaluate the efficacy of olanzapine in managing nausea and vomiting in advanced cancer patients.
- To assess olanzapine's role in both preventing and treating chemotherapy-induced nausea and vomiting (CINV).
- To explore olanzapine's potential for treating chronic nausea and vomiting unrelated to cancer treatment.
Main Methods:
- Review of recent randomized clinical trials.
- Analysis of olanzapine's effectiveness in various nausea and vomiting scenarios in cancer patients.
Main Results:
- Olanzapine demonstrated effectiveness in preventing chemotherapy-induced nausea and vomiting (CINV).
- Olanzapine was also effective in treating established CINV.
- Recent trials indicate olanzapine's utility in managing chronic nausea and vomiting unrelated to cancer treatment.
Conclusions:
- Olanzapine is a potentially effective agent for managing chemotherapy-induced nausea and vomiting (CINV).
- Olanzapine may offer a new therapeutic option for chronic nausea and vomiting in advanced cancer patients.
- Further research supports olanzapine's role in improving symptom control for cancer patients experiencing nausea and vomiting.
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