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Oxidative Stress in Autism Spectrum Disorder
Geir Bjørklund1, Nagwa A Meguid2,3, Mona A El-Bana3,4
1Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway. bjorklund@conem.org.
Molecular Neurobiology
|February 7, 2020
Summary
Oxidative stress is linked to autism spectrum disorder (ASD) in children. Early assessment and treatment of antioxidant status may improve outcomes by reducing brain damage in children with ASD.
Area of Science:
- Neuroscience
- Pediatrics
- Biochemistry
Background:
- Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting socialization, language, and behavior.
- ASD affects 1 in 68 children in the USA, presenting a significant public health challenge.
- There are no apparent physical differences in children with ASD, making it a hidden disability.
Purpose of the Study:
- To review the role of oxidative stress in ASD pathophysiology.
- To explore oxidative stress as a potential therapeutic target for ASD.
Main Methods:
- Review of existing studies on oxidative stress markers in ASD.
- Analysis of the association between redox imbalance and ASD.
Main Results:
- Children with ASD exhibit increased indicators of oxidative stress, including reactive oxygen species and lipid peroxidation.
- ASD is associated with an imbalance in glutathione levels, increasing vulnerability to oxidative stress.
- Redox imbalance is considered integral to ASD pathophysiology.
Conclusions:
- Oxidative stress plays a significant role in the development and progression of ASD.
- Early assessment and intervention targeting antioxidant status may mitigate irreversible brain damage.
- Targeting oxidative stress presents a promising therapeutic avenue for managing ASD.
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