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Updated: Dec 29, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Cardiovascular Function in Obstructive Sleep Apnea Patients with Controlled Hypertension.

Magdalena Kostrzewska1, Marcin Grabicki2, Tomasz Piorunek1

  • 1Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, Poznan, Poland.

Advances in Experimental Medicine and Biology
|February 7, 2020
PubMed
Summary

Obesity, not hypertension, drives hemodynamic changes in men with obstructive sleep apnea (OSA). This finding highlights the critical role of weight management in managing OSA patients with high blood pressure.

Keywords:
Arterial blood pressureBody massCardiovascular functionHemodynamicsHypertensionObesityObstructive sleep apnea

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Area of Science:

  • Cardiovascular Physiology
  • Sleep Medicine
  • Obesity Research

Background:

  • Obstructive sleep apnea (OSA) is frequently comorbid with hypertensive disease.
  • The independent contribution of OSA versus obesity to hemodynamic alterations in hypertensive patients remains unclear.

Purpose of the Study:

  • To investigate the hemodynamic profile of obese men with severe OSA and controlled hypertension.
  • To differentiate the hemodynamic effects of OSA from those of obesity.

Main Methods:

  • Noninvasive impedance cardiography and radial artery tonometry were used to assess hemodynamic parameters.
  • Peripheral and central aortic pressure waveforms were reconstructed.
  • Patients with severe OSA (apnea-hypopnea index ≥ 30) and controlled blood pressure (≤ 140/90 mmHg) were compared to healthy normotensive controls.

Main Results:

  • Obese OSA patients exhibited higher body mass index (BMI) compared to controls.
  • OSA patients showed faster heart rate, increased peripheral pulse pressure, and reduced myocardial contractility indices.
  • These hemodynamic differences became non-significant after adjusting for BMI, indicating obesity as the primary driver.

Conclusions:

  • Obesity, characterized by a significantly higher BMI, is the main contributor to adverse hemodynamic changes observed in obese men with obstructive sleep apnea and controlled hypertension.
  • These findings underscore the importance of weight management in mitigating cardiovascular risks associated with OSA.