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Neural dysfunction during hypoglycaemia.

T H Koh1, A Aynsley-Green, M Tarbit

  • 1Department of Child Health, University of Newcastle upon Tyne.

Archives of Disease in Childhood
|November 1, 1988
PubMed
Summary

Hypoglycemia (low blood sugar) can affect children even without symptoms. Maintaining blood glucose above 2.6 mmol/l is crucial for normal neural function in pediatric patients.

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Area of Science:

  • Pediatric Endocrinology
  • Neurophysiology

Background:

  • Controversy exists regarding the definition and significance of hypoglycemia in children, particularly asymptomatic cases.
  • Assessing the impact of low blood glucose on neural function in pediatric populations is critical.

Purpose of the Study:

  • To investigate the relationship between blood glucose concentration and neural function in children.
  • To determine the critical blood glucose threshold for maintaining normal neural function in pediatric patients.

Main Methods:

  • Measured sensory evoked potentials in relation to blood glucose levels in 17 children.
  • Included children undergoing fasting or insulin administration for metabolic investigations and those with spontaneous hypoglycemia.
  • Monitored blood glucose concentrations and correlated them with evoked potential abnormalities.

Main Results:

  • Abnormal evoked potentials were observed in 10 out of 11 children with blood glucose below 2.6 mmol/l.
  • Five of these children with abnormal evoked potentials were asymptomatic.
  • No evoked potential changes were noted in children with blood glucose levels above 2.6 mmol/l.

Conclusions:

  • Blood glucose levels below 2.6 mmol/l are associated with abnormal neural function in children, even in the absence of clinical symptoms.
  • Maintaining blood glucose above 2.6 mmol/l is recommended to ensure normal neural function in children.
  • This threshold is important for defining and managing hypoglycemia in pediatric care.

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