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Sleep quality and chronic neck pain: a cotwin study
Alessandro Andreucci1,2, Juan J Madrid-Valero3, Paulo H Ferreira4
1Center for General Practice at Aalborg University, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Summary
Genetic factors partially explain the link between poor sleep quality and chronic neck pain (NP). This twin study found that while both issues are linked, shared genetic influences play a role in their association.
Area of Science:
- Twin studies
- Genetics
- Sleep science
- Pain research
Background:
- Sleep quality and chronic neck pain (NP) are known to be associated.
- Genetic influences on this association have not been previously explored.
Purpose of the Study:
- To investigate the genetic and environmental influences on the association between sleep quality and chronic NP.
Main Methods:
- Utilized data from 2,328 individual twins from the Murcia Twin Registry (Spain).
- Employed bidirectional cotwin logistic regression analysis, assessing sleep quality as exposure and NP as outcome, and vice versa.
- Conducted analysis in two stages: total sample analysis and within-pair twin case-control analysis.
Main Results:
- Poor sleep quality was significantly associated with chronic NP (OR: 1.09 in total sample, OR: 1.10 in cotwin analysis).
- Chronic NP was significantly associated with poor sleep quality (OR: 1.80 in total sample, OR: 1.63 in cotwin analysis).
- Associations were significant in dizygotic twin pairs but not in monozygotic pairs, suggesting partial genetic confounding.
Conclusions:
- The association between sleep quality and chronic NP is partially confounded by genetic factors.
- Findings highlight the complex interplay between genetic predispositions, sleep disturbances, and chronic pain conditions.
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