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Structural optimality and neurogenetic expression mediate functional dynamics in the human brain.

Ioannis Pappas1,2,3, Michael M Craig1,2, David K Menon1,2

  • 1Division of Anaesthesia, Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

Human Brain Mapping
|February 7, 2020
PubMed
Summary
This summary is machine-generated.

Brain network communication relies on specific structural connections. Optimal connections predict resting-state function, while non-optimal ones predict task-based function, linked to neurotransmission genes.

Keywords:
functional connectivitygame theorymicroarrayoptimalitypredictionstructural connectivity

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Genetics

Background:

  • The human brain's functional connectivity is complex but its development from fixed structural anatomy is unclear.
  • Understanding how structural connections support dynamic functional networks during rest and cognitive tasks is crucial.

Purpose of the Study:

  • To investigate if optimal structural brain connections predict resting-state functional connectivity.
  • To determine if non-optimal connections predict functional connectivity during cognitive tasks.
  • To explore the link between structural-functional relationships, network navigation, and gene expression.

Main Methods:

  • Utilized a game-theoretic model to identify optimal structural connections within the human structural connectome.
  • Employed structural connection data from 50 healthy individuals.
  • Integrated structural connectivity, functional connectivity (resting-state and task-based), and gene expression data.

Main Results:

  • Optimal structural connections accurately predicted resting-state functional connectivity.
  • Non-optimal structural connections accurately predicted functional connectivity during a working memory task.
  • A balance between optimal and non-optimal connections correlated with gene expression related to neurotransmission.

Conclusions:

  • Brain structure-function relationships are dynamic, depending on the cognitive state (rest vs. task).
  • The brain utilizes different white matter pathways for information processing based on network demands.
  • Genetic profiles, specifically neurotransmission-related genes, may influence these structure-function dynamics.