Related Experiment Video
Updated: Dec 29, 2025
07:27
Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
10.6K
HIV Care Among Elderly Population: Systematic Review and Meta-Analysis
Mihir Bhatta1, Srijita Nandi1, Nalok Dutta1
1Divisions of Virology and ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.
AIDS Research and Human Retroviruses
|February 7, 2020
Summary
The number of elderly people living with HIV is rising, with a significant portion of new diagnoses in the US occurring in those over 50. This study reveals a 15.79% pooled HIV prevalence in the elderly, with low viral suppression rates.
Area of Science:
- Gerontology
- Infectious Diseases
- Public Health
Background:
- The global population of elderly individuals living with HIV (Human Immunodeficiency Virus) is increasing.
- Delayed diagnosis and treatment in this demographic are common due to co-occurring life-threatening diseases and healthcare system factors.
- Nearly half of new HIV diagnoses in the United States are among individuals over 50 years old.
Purpose of the Study:
- To determine the pooled prevalence of HIV in the elderly population.
- To assess the current continuum of care for elderly HIV patients.
- To identify challenges in HIV management for older adults.
Main Methods:
- Systematic review and meta-analysis of 28 studies published between 2000 and 2018.
- Data retrieval from major scientific databases including MEDLINE, PubMed, Cochrane Library, EMBASE, and Google Scholar.
- Statistical analysis using DerSimonian and Laird Random Effects model, STATA 13.0, and Q-GIS for mapping, with heterogeneity and bias assessed by I² statistics.
Main Results:
- The pooled prevalence of HIV in the elderly population was found to be 15.79%.
- Antiretroviral therapy (ART) coverage was moderate at 38.64%, with a low viral suppression rate of 11.52%.
- ART retention rates were 12.77%, and mortality was 6.15%, with challenges including drug interactions and comorbidities.
Conclusions:
- Elderly HIV patients face significant challenges in achieving viral suppression, despite ART availability.
- Comorbidities and drug interactions negatively impact treatment outcomes and lifespan in this population.
- Improved healthcare strategies are needed to enhance HIV care continuum for aging individuals.
More Related Videos
Related Concept Videos
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
147
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
147
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
147
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
147
01:15Drug Dosing: Geriatric Patients
175
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
175
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
156
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
156
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
175
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
175
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
194
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
194