Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple sclerosis with early childhood onset. A case report.

M I Vergani1, R Reimão, A M Silva

  • 1Department of Neurology, University of São Paulo School of Medicine, Brasil.

Arquivos De Neuro-Psiquiatria
|June 1, 1988
PubMed
Summary

Pediatric multiple sclerosis (MS) can present with neurological deficits like ataxia and hearing loss. Early diagnosis is crucial, supported by imaging and cerebrospinal fluid analysis, even in young children.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perspectives on the impact of regulatory measures on national COVID-19 vaccination programs: a qualitative study from six EU member states.

Journal of pharmaceutical policy and practice·2025
Same author

Real-World Evidence on the Effectiveness and Safety of Spesolimab in the Treatment of Generalized Pustular Psoriasis Flares: A Case Series.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2025
Same author

Exploring wide gap semiconductor characteristics in <math></math> -pinene crystals: insights from density functional theory.

Journal of molecular modeling·2024
Same author

Effect of glycoelectrolytic supplement on post-weaning piglet performance and intestinal integrity.

Tropical animal health and production·2023
Same author

On the structural, electronic, and optical properties of L-histidine crystal: a DFT study.

Journal of molecular modeling·2023
Same author

Establishment of methods to analyze the structural and functional integrity of the quail (<i>Coturnix coturnix japonica</i>) sperm plasma membrane.

British poultry science·2023

Area of Science:

  • Pediatric Neurology
  • Neuroimmunology
  • Clinical Diagnostics

Background:

  • Multiple sclerosis (MS) is typically diagnosed in adults, but rare cases occur in early childhood.
  • Diagnosing pediatric MS presents challenges due to overlapping symptoms with other neurological conditions.

Observation:

  • A 2-year-old boy experienced subacute ataxic gait and hearing loss, with elevated cerebrospinal fluid (CSF) gamma globulins.
  • A subsequent episode at age 5 showed appendicular ataxia, gaze deviation, white matter lesions on CT, abnormal evoked potentials, and altered T lymphocyte subsets.

Findings:

  • The patient exhibited recurrent neurological episodes with visual, cerebellar, brainstem, and paraventricular involvement.
  • Diagnostic support included abnormal CSF gamma globulin levels, T lymphocyte subset analysis, and neuroimaging (CT).

Related Experiment Videos

  • Evoked potentials studies revealed abnormalities in both auditory and visual pathways.

    • Implications:

    • The clinical presentation and diagnostic findings strongly suggest multiple sclerosis (MS) in this pediatric patient.
    • This case highlights the importance of considering MS in young children presenting with unexplained neurological symptoms and relapsing-remitting courses.
    • Early identification and diagnosis of pediatric MS are critical for timely intervention and management.