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The effects of proton pump inhibitors on the microbiome in young children

Elvira I Levy1, Delphine M Hoang1, Yvan Vandenplas1

  • 1KidZ Health Castle, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Acta Paediatrica (Oslo, Norway : 1992)
|February 7, 2020
PubMed

Insights

Proton pump inhibitors (PPIs) alter the microbiome in children, leading to adverse effects. While probiotics may help, their effectiveness in preventing PPI-induced issues requires further research.

Area of Science:

  • Microbiology
  • Pediatric Gastroenterology
  • Pharmacology

Background:

  • Proton pump inhibitor (PPI) use is rising globally in pediatric populations.
  • Understanding the impact of PPIs on the pediatric microbiome is crucial.

Purpose of the Study:

  • To review the effects of PPIs on the pediatric microbiome.
  • To examine associated impacts on gastrointestinal, respiratory, and metabolic systems.
  • To discuss the potential role of probiotics.

Main Methods:

  • Literature search conducted in PubMed and Google Scholar.
  • Included English-language articles relevant to PPIs and the pediatric microbiome.
  • Extracted data based on keywords and subject headings.

Main Results:

  • PPIs alter the oral, gut, and lung microbiomes in children.
  • Adverse effects include necrotizing enterocolitis, sepsis, C. difficile infection, asthma, obesity, and SIBO.
  • Limited studies exist on probiotics counteracting PPI-induced adverse effects.

Conclusions:

  • PPIs induce microbiome dysbiosis in pediatric patients.
  • Probiotics show potential for restoring dysbiosis.
  • Further research is needed on probiotics preventing PPI-related adverse effects.
Abstract

Keywords:
H2 receptor antagonistLactobacillusmicrobiomeprobioticproton pump inhibitorsmall intestinal bacterial overgrowth

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