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Leukocyte changes associated with acute inflammation in chickens.
K S Latimer1, K N Tang, M A Goodwin
1Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Avian Diseases
|October 1, 1988
Summary
Turpentine-induced inflammation in chickens causes significant leukocytosis and heterophilia, with peak counts observed at specific time points. Leukocyte changes and toxic heterophil alterations resolved by 14 days, indicating a return to baseline conditions.
Area of Science:
- Avian pathology
- Inflammatory response
- Hematology
Background:
- Inflammation is a complex biological response to harmful stimuli.
- Understanding leukocyte dynamics is crucial for diagnosing and managing avian diseases.
Purpose of the Study:
- To sequentially investigate leukocyte count and morphology changes in chickens following turpentine-induced inflammation.
- To characterize the temporal dynamics of inflammatory cell responses and toxic changes in heterophils.
Main Methods:
- Turpentine was administered to induce acute inflammation in chickens.
- Leukocyte differential counts were performed at multiple time points (0, 6, 12, 24 hours; 2, 3, 4, 7, 14 days).
- Heterophil nuclear morphology and ultrastructural changes were analyzed.
Main Results:
- Significant leukocytosis and heterophilia were observed by 6 hours, peaking at 12 hours and 3 days, respectively.
- Left shifts were noted early, with hyposegmentation and toxic changes in heterophils, resolving by 14 days.
- Monocyte and lymphocyte counts peaked at 2 and 3 days, while basophil and eosinophil counts were variable.
Conclusions:
- Turpentine-induced inflammation triggers distinct sequential changes in chicken leukocyte populations.
- Toxic heterophil changes, including ultrastructural alterations, are characteristic of acute inflammation and resolve over time.
- Hematological parameters returned to baseline by 14 days post-induction, signifying complete recovery.