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Updated: Dec 29, 2025
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Pathophysiologic and Therapeutic Perspectives Based on Thrombus Histology in Stroke
Ji Hoe Heo1,2, Hyo Suk Nam1,2, Young Dae Kim1,2
1Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
Journal of Stroke
|February 7, 2020
Summary
Histologic analysis of acute stroke thrombi reveals diverse compositions, impacting endovascular thrombectomy effectiveness. Understanding thrombus features aids stroke prevention and improves reperfusion therapies.
Area of Science:
- Neurology
- Pathology
- Cardiovascular Research
Background:
- Endovascular thrombectomy for acute stroke allows direct thrombus analysis.
- Thrombus composition varies significantly among patients.
- Thrombus characteristics influence treatment efficacy and patient outcomes.
Purpose of the Study:
- To investigate the heterogeneity of thrombus composition in acute stroke.
- To correlate thrombus features with endovascular thrombectomy outcomes.
- To explore the role of neutrophils and extracellular traps in thrombus formation and resistance.
Main Methods:
- Histopathologic analysis of fresh thrombi from acute stroke patients.
- Comparison of thrombus composition between cardiac and arterial sources.
- Evaluation of thrombus age and its relation to reperfusion therapy success.
Main Results:
- Significant heterogeneity in thrombus composition and component distribution was observed.
- Differences in thrombus patterns were noted between cardiac and arterial thrombi.
- Neutrophils and neutrophil extracellular traps were implicated in thrombus formation and reperfusion resistance.
Conclusions:
- Histologic features of stroke thrombi offer insights into etiology and guide prevention strategies.
- Thrombus analysis can inform and improve endovascular thrombectomy and reperfusion therapies.
- Further research into thrombus composition may lead to novel therapeutic agents.
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