Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.5K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.5K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

1.9K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.9K
Introduction to Hemostasis01:05

Introduction to Hemostasis

12.7K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
12.7K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

228
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
228
Therapeutic Index01:13

Therapeutic Index

6.3K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.3K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

11.5K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
11.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indirect measurement of research misconduct among Iranian postgraduate students of medical sciences using the unmatched count technique.

Research integrity and peer review·2026
Same author

Otologic Manifestations of Temporomandibular Disorders.

Diagnostics (Basel, Switzerland)·2026
Same author

Marker-trait association analysis revealed loci linked to salinity tolerance in a worldwide collection of safflower.

Scientific reports·2026
Same author

Update on the interaction of notch and Wnt/β-catenin signaling in neural stem cells and brain homeostasis during ischemic stroke.

Tissue & cell·2026
Same author

Development of a pyrogallol-formaldehyde resin column for one-step pre-purification of <sup>68</sup>Ge/<sup>68</sup>Ga generator eluates: Enhanced [<sup>68</sup>Ga]Ga-DOTA-TATE radiolabeling yield by selective removal of tetravalent cationic impurities.

Nuclear medicine and biology·2026
Same author

Evaluating the Effectiveness of Empathy Training for Women in Prison in Iran: An Exploratory Trial of an Empathy Training Group for Its Impact on Aggression, Moral Disengagement and Moral Identity.

Criminal behaviour and mental health : CBMH·2026

Related Experiment Video

Updated: Dec 29, 2025

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
08:40

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Published on: June 8, 2016

14.6K

Medicinal Plants as Potential Hemostatic Agents.

Fatemeh Ebrahimi1, Mohammadali Torbati, Javad Mahmoudi

  • 1School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques
|February 7, 2020
PubMed
Summary

Medicinal plants show hemostatic activity, aiding new drug discovery for bleeding disorders. This review identifies 17 plants and their compounds, highlighting potential benefits and risks like toxicity.

More Related Videos

A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine
08:27

A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine

Published on: December 6, 2024

595
Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
09:01

Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse

Published on: April 2, 2017

10.1K

Related Experiment Videos

Last Updated: Dec 29, 2025

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
08:40

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Published on: June 8, 2016

14.6K
A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine
08:27

A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine

Published on: December 6, 2024

595
Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
09:01

Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse

Published on: April 2, 2017

10.1K

Area of Science:

  • Ethnobotany
  • Pharmacology
  • Phytochemistry

Background:

  • Medicinal plants are vital sources for novel drug discovery.
  • Traditional medicine widely uses herbs for various ailments, including bleeding.
  • Ethnomedicinal uses of plants for hemostasis are globally prevalent.

Purpose of the Study:

  • To comprehensively review medicinal plants and their compounds with hemostatic effects.
  • To document ethnomedicinal uses related to stimulating the hemostasis process.
  • To identify plant-derived agents for potential therapeutic applications in bleeding.

Main Methods:

  • Systematic literature search across major electronic databases (PubMed, EMBASE, Web of Science).
  • Inclusion of studies detailing ethnomedicinal use and demonstrated hemostatic activity.
  • Extraction and analysis of relevant data on plant species, compounds, and mechanisms.

Main Results:

  • 17 medicinal plants exhibiting hemostatic activity were identified.
  • Commonly studied families include Compositae, Lamiaceae, Fabaceae, and Asteraceae.
  • Key bioactive compounds include tannins, iridoid glycosides, and phenolic compounds.
  • Mechanisms involve coagulation stimulation, fibrinolysis inhibition, vasoconstriction, and platelet aggregation.
  • Adverse effects such as hepatotoxicity and nephrotoxicity were noted at high doses.

Conclusions:

  • Identified medicinal plants offer potential as novel plant-based hemostatic agents.
  • This review aids in understanding plant interactions with anticoagulant and antiplatelet medications.
  • Further research can explore the therapeutic potential and safety profiles of these hemostatic plants.