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Growth related changes in protein synthesis and in a 25 kDa protein of Ehrlich ascites tumor cells
H Bielka1, R Benndorf, I Junghahn
1Department of Cell Physiology, Academy of Sciences of the GDR, Berlin Buch.
Biomedica Biochimica Acta
|January 1, 1988
Abstract:
The decrease of the in vivo growth rate of the Ehrlich ascites tumor after intraperitoneal injection of carcinoma cells into mice is correlated with (1) a decline in the overall rate of cellular protein synthesis, (2) a corresponding decrease of the activity of the cytosolic fraction to stimulate in vitro polysomal protein synthesis, (3) the abundance and phosphorylation of a 25 kDa protein. The results are discussed with respect to correlations between the regulation of protein synthesis and cell proliferation.